Loksha, Yasser M.’s team published research in Archiv der Pharmazie (Weinheim, Germany) in 349 | CAS: 5738-14-7

Archiv der Pharmazie (Weinheim, Germany) published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Product Details of C6H9N3O2.

Loksha, Yasser M. published the artcileSynthesis and Anti-HIV-1 Evaluation of Some Novel MC-1220 Analogs as Non-Nucleoside Reverse Transcriptase Inhibitors, Product Details of C6H9N3O2, the publication is Archiv der Pharmazie (Weinheim, Germany) (2016), 349(5), 363-372, database is CAplus and MEDLINE.

Some novel MC-1220 analogs were synthesized by a condensation of 4,6-dichloro-N-methylpyrimidin-2-amine derivatives and/or 4-chloro-6-methoxy-N,N,5-trimethylpyrimidin-2-amine with the sodium salt of 2,6-difluorophenylacetonitrile followed by treatment with aqueous sodium hydroxide in methanol, alkylation, reduction, halogenation, and/or acidic hydrolysis. All synthesized compounds were evaluated for their activity against HIV-1. The most active compound in this study showed activity against HIV-1 comparable to that of MC-1220. The only difference in structure between compound 7 and MC-1220 is a fluoro atom instead of a CH3 group.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 5738-14-7. 5738-14-7 belongs to pyrimidines, auxiliary class Pyrimidine,Amine,Alcohol,Pyrimidine, name is 2-(Dimethylamino)pyrimidine-4,6-diol, and the molecular formula is C6H9N3O2, Product Details of C6H9N3O2.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/Pyrimidine,
Pyrimidine – Wikipedia