Anti-herpesvirus activity profile of 4′-thioarabinofuranosyl purine and uracil nucleosides and activity of 1-β-D-2′-fluoro-4′-thioarabinofuranosyl guanine and 2,6-diaminopurine against clinical isolates of human cytomegalovirus was written by Machida, Haruhiko; Ashida, Noriyuki; Miura, Shinji; Endo, Mikari; Yamada, Kohei; Kitano, Kenji; Yoshimura, Yuichi; Sakata, Shinji; Ijichi, Osamu; Eizuru, Yoshito. And the article was included in Antiviral Research on August 31,1998.Synthetic Route of C10H13FN2O5 The following contents are mentioned in the article:
Newly synthesized 4′-thio- and 2′-fluoro-4′-thioarabinofuranosyl purine and pyrimidine nucleosides were compared with the corresponding 4′-oxo type arabinosyl nucleosides for anti-herpesvirus and anti-cell proliferative potencies. 4′-Thioarabinosyl- and 2′-fluoro-4′-thioarabinofuranosyl 5-substituted uracils had selective antiviral activities, but were not superior to 4′-oxo nucleosides, except for the activity of 5-ethyluracil-4′-thio nucleosides against herpes simplex virus. Furthermore, 4′-thio substituted derivatives of sorivudine (BV-araU) and related compounds, and 2′-fluoro-5-methylarabinosyluracil exhibited reduced activity against varicella-zoster virus compared with the parent compounds The 4′-thioarabinosyluracils, except for 5-methyluracil derivatives, were inactive against human cytomegalovirus (HCMV). 4′-Thioarabinofuranosyl guanine and diaminopurine had the most potent anti-HCMV and anti-proliferative activities, whereas arabinosyl guanine and diaminopurine had only marginal antiviral activity. 2′-Fluoro-4′-thioarabinofuranosyl derivatives of guanine (4′-thio-FaraG) and 2,6-diaminopurine (4′-thio-FaraDAP), however, had particularly high activity against all herpesviruses tested with anti-proliferative activity equipotent to that of arabinosyl guanine and diaminopurine. 4′-Thio- and 2′-fluoro-4′-thioarabinofuranosyladenines exhibited biol. activities similar to that of arabinosyladenine. Both 4′-thio-FaraG and 4′-thio-FaraDAP had a 6-fold lower ED50 than ganciclovir against clin. isolates of HCMV. A ganciclovir-resistant isolate, obtained from a patient who had received long-term ganciclovir-treatment, was susceptible to 4′-thio-FaraG and 4′-thio-FaraDAP. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Synthetic Route of C10H13FN2O5).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Synthetic Route of C10H13FN2O5
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3