In vitro and in vivo anti-HSV activities of 1-β-D-arabinofuranosyl-E-5-(2-halogenovinyl)uracil was written by Machida, Haruhiko; Sakata, Shinji; Kuninaka, Akira; Yoshino, Hiroshi. And the article was included in International Congress Series in 1982.Safety of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione The following contents are mentioned in the article:
E-5-(2-bromovinyl)arabinosyluracil (I) [77181-69-2] and E-5-(2-chlorovinyl)arabinosyluracil [77181-70-5] were slightly more effective against herpes simplex virus-1 (HSV-1) infection, but much less effective against HSV-2 infection as compared to 5-vinylarabinosyluracil [74886-33-2]. Thus, substitution of a H with a halogen at C-2 of the vinyl group increased the anti-HSV-1 activity of vinylarabinosyluracil but weakened its anti-HSV-2 activity. The anti-HSV-1 activity of I was almost equal to that of E-5-(2-bromovinyl)-2′-deoxyuridine BV-dUrd) [69304-47-8], 2′-fluoro-5-iodoarabinosylcytosine [69123-90-6], and 2′-fluoro-5-methylarabinosyluracil [69256-17-3]. I was less inhibitory to the growth of HEL-F cells than BV-dUrd. Thus, replacement of the deoxyribose moiety by arabinose in 5-vinyl and 5-halogenvinyl derivatives of 2′-deoxyuridines seems to weaken anticellular activity without significant loss of antiviral activity. The selectivity of I against HVS-1 was confirmed in terms of inhibition of DNA formation in HSV-1 infected cells. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Safety of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Safety of 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3