On May 23, 2013, Madge, David; Chan, Fiona; John, Derek Edward; Edwards, Simon D.; Blunt, Richard; Hartzoulakis, Basil; Brown, Lindsay published a patent.SDS of cas: 42518-42-3 The title of the patent was Thienopyrimidines, furopyrimidines, thienopyridines and furopyridines useful as potassium channel inhibitors and their preparation. And the patent contained the following:
The invention provides compounds of formula I which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula I and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof. Compounds of formula I wherein A is O and S; X, V and Z are independently N and CR4, wherein one of two of V, X and Z are N; R1 is (un)substituted alkyl, (un)substituted cycloalkyl, (un)substituted aryl and (un)substituted heteroaryl; R2 is H, halo, CN, CF3, etc.; R3 is H, halo, CN, CF3, (un)substituted alkyl, etc.; each R4 is independently H, halo, CN, CF3, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by N-alkylation of 2-(1-methylpyrrolidin-2-yl)ethanamine with 4-[4-(bromomethyl)-1-piperidyl]-5-phenyl-thieno[2,3-d]pyrimidine. The invention compounds were evaluated for their potassium channel inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of less than 500 nM. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).SDS of cas: 42518-42-3
The Article related to thienopyrimidine furopyrimidine thienopyridine furopyridine preparation potassium channel inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 42518-42-3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia