H1-antihistaminic and antimuscarinic effects of 2- and 4-[benzyl-(2-dimethylaminoethyl)amino]pyrimidine compounds was written by Maggiali, C.;Morini, Giovanni;Mossini, F.;Morini, Giuseppina;Barocelli, E.;Impicciatore, M.. And the article was included in Farmaco, Edizione Scientifica in 1988.Name: 4-Chloro-2-methoxypyrimidine This article mentions the following:
Fourteen 2- (I) and 4-[benzyl-(2-dimethylaminoethyl)amino]pyrimdidines (II) (in both cases R, R1 and R3 = OMe or H; R2 = SMe, Cl, or H) were prepared In tests on the isolated guinea pig ileum, I were more potent than II as antihistaminics, but the only compound which was a pure H1-antihistaminic was II (R = R1 = OMe; R2 = R3 = H), which had a potency similar to that of tonzylamine. In the same test system, the only compound to display a specific antimuscarinic activity (though of low potency) was II (R = R3 = H; R1 = OMe; R2 = Sme). Structure-activity relations are discussed in detail. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-methoxypyrimidine (cas: 51421-99-9Name: 4-Chloro-2-methoxypyrimidine).
4-Chloro-2-methoxypyrimidine (cas: 51421-99-9) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Name: 4-Chloro-2-methoxypyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia