The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Synthetic Route of 2927-71-1.
Mandal, Mihirbaran;Wu, Yusheng;Misiaszek, Jeffrey;Li, Guoqing;Buevich, Alexei;Caldwell, John P.;Liu, Xiaoxiang;Mazzola, Robert D.;Orth, Peter;Strickland, Corey;Voigt, Johannes;Wang, Hongwu;Zhu, Zhaoning;Chen, Xia;Grzelak, Michael;Hyde, Lynn A.;Kuvelkar, Reshma;Leach, Prescott T.;Terracina, Giuseppe;Zhang, Lili;Zhang, Qi;Michener, Maria S.;Smith, Brad;Cox, Kathleen;Grotz, Diane;Favreau, Leonard;Mitra, Kaushik;Kazakevich, Irina;McKittrick, Brian A.;Greenlee, William;Kennedy, Matthew E.;Parker, Eric M.;Cumming, Jared N.;Stamford, Andrew W. research published 《 Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates》, the research content is summarized as follows. We describe successful efforts to optimize the in vivo profile and address off-target liabilities of a series of BACE1 inhibitors represented by 6 that embodies the recently validated fused pyrrolidine iminopyrimidinone scaffold. Employing structure-based design, truncation of the cyanophenyl group of I that binds in the S3 pocket of BACE1 followed by modification of the thienyl group in S1 was pursued. Optimization of the pyrimidine substituent that binds in the S2′-S2” pocket of BACE1 remediated time-dependent CYP3A4 inhibition of earlier analogs in this series and imparted high BACE1 affinity. These efforts resulted in the discovery of difluorophenyl analog II (MBi-4), which robustly lowered CSF and cortex Aβ40 in both rats and cynomolgus monkeys following a single oral dose. II represents a unique mol. shape among BACE inhibitors reported to potently lower central Aβ in nonrodent preclin. species.
Synthetic Route of 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia