On December 14, 2017, Mansour, Tarek Suhayl; Chafeev, Mikhail; Yudin, Mikhail; Gezentsvey, Yury; Nikitin, Aleksandr published a patent.COA of Formula: C7H9ClN2 The title of the patent was Preparation of compounds containing benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide or benzo[d][1,3]oxathiole 3,3-dioxide and methods/uses thereof as agonists of g protein-coupled receptor 119. And the patent contained the following:
There are provided benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide, and benzo[d][1,3]oxathiole 3,3-dioxide compounds of formula I, as well as uses/methods related thereto, including treatment of diseases and condition associated with GPR119 dysregulation, type 2 diabetes mellitus, and related metabolic disorders. Compounds of formula I wherein one of X1 and X2 is O and the other one is SO2; X3 is CH, CF and N; X4 is independently CH and N; A is (un)substituted piperazinyl, (un)substituted pyrrolidinyl, (un)substituted piperidinyl, etc.; and enantiomers, diastereomers, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, are claimed. Example compound II was prepared by etherification of (1-tert-butylpiperidin-4-yl)methanol with 4-(3,3-dioxido-1,3-benzoxathiol-6-yl)-2-fluorophenol. The invention compounds were evaluated for their GPR119 agonistic activity. From the assay, it was determined that compound II exhibited EC50 value of 833 nM and 75 % of cAMP stimulation. The experimental process involved the reaction of 2-Chloro-5-isopropylpyrimidine(cas: 596114-50-0).COA of Formula: C7H9ClN2
The Article related to benzoxathiole oxide preparation gpr119 agonist, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C7H9ClN2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia