Effects of certain nucleoside analogs on human cytomegalovirus replication in vitro was written by Mar, Engchun; Patel, Pravin C.; Cheng, Yungchi; Fox, Jack J.; Watanabe, Kyoichi A.; Huang, Engshang. And the article was included in Journal of General Virology on January 31,1984.COA of Formula: C10H13FN2O5 The following contents are mentioned in the article:
Four nucleoside analogs, 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyluracil (I), -5-iodouracil (II), -5-methylcytosine (III) and -5-iodocytosine (IV), were studied for their effect on human cytomegalovirus (HCMV) replication in vitro. I, II, III, and IV showed antiviral activities for 4 strains of HCMV (Major, Clegg, D550 and Towne) in a plaque reduction assay, with ED50s in the range of 0.1-0.65 μM. At 1 μM I or IV, the synthesis of 5 virus-specific late polypeptides was entirely blocked. Quantification of Towne viral DNA synthesis, using complementary RNA-DNA hybridization with a Towne-specific cRNA probe, demonstrated a complete inhibition of HCMV DNA replication at 1 μM I or IV. After the removal of the inhibitors, however, viral DNA synthesis resumed, and infectious virus reappeared, indicating that the inhibition of HCMV replication by these nucleoside analogs was of a virostatic reversible type. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3COA of Formula: C10H13FN2O5).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.COA of Formula: C10H13FN2O5
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3