Martin, Joseph A. et al. published their research in Journal of Medicinal Chemistry in 1990 | CAS: 56632-83-8

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 56632-83-8

Synthesis and antiviral activity of monofluoro and difluoro analogs of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1) was written by Martin, Joseph A.; Bushnell, David J.; Duncan, Ian B.; Dunsdon, Stephen J.; Hall, Michael J.; Machin, Peter J.; Merrett, John H.; Parkes, Kevin E. B.; Roberts, Noel A.. And the article was included in Journal of Medicinal Chemistry on August 31,1990.Related Products of 56632-83-8 The following contents are mentioned in the article:

2′-Fluoro and 2′,3′-difluoro analogs of pyrimidine deoxyribonucleosides were synthesized and evaluated against HIV-1 in a human lymphoblastoid cell line. Among these compounds, (dideoxyfluoropentofuranosyl)cytosine I (R = H), didehydrodideoxyfluorocytidine II, (dideoxydifluorofuranosyl)cytosine I (R = F) and deoxydidehydrofluorothymidine III were found to have significant antiviral activity, with inhibiting concentration50 values of 0.65, 10, 10, and 100 μM, resp. The structure-activity relationships are discussed. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Related Products of 56632-83-8).

4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Related Products of 56632-83-8

56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8