Martinez-Gonzalez, Sonia et al. published their research in ACS Medicinal Chemistry Letters in 2021 | CAS: 175137-21-0

4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine

Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors was written by Martinez-Gonzalez, Sonia;Alvarez, Rosa M.;Martin, Jose I.;Garcia, Ana Belen;Riesco-Fagundo, Concepcion;Varela, Carmen;Rodriguez Hergueta, Antonio;Gonzalez Cantalapiedra, Esther;Albarran, M. I.;Gomez-Casero, Elena;Cebria, Antonio;Aguirre, Enara;Ajenjo, Nuria;Cebrian, David;Di Geronimo, Bruno;Cunningham, Darren;O閳ョ澇eill, Michael;Dave, Harish P. G.;Blanco-Aparicio, Carmen;Pastor, Joaquin. And the article was included in ACS Medicinal Chemistry Letters in 2021.Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine This article mentions the following:

The PI3K/AKT/mTOR and PIM kinase pathways contribute to the development of several hallmarks of cancer. Cotargeting of these pathways has exhibited promising synergistic therapeutic effects in liquid and solid tumor types. To identify mols. with combined activities, we cross-screened our collection of PI3K/(鍗TOR) macrocycles (MCXs) and identified the MCX thieno[3,2-d]pyrimidine derivative 2 as a moderate dual PI3K/PIM-1 inhibitor. We report the medicinal chem. exploration and biol. characterization of a series of thieno[3,2-d]pyrimidine MCXs, which led to the discovery of IBL-302 (31), a potent, selective, and orally bioavailable triple PI3K/mTOR/PIM inhibitor. IBL-302, currently in late preclin. development (AUM302), has recently demonstrated efficacy in neuroblastoma and breast cancer xenografts. Addnl., during the course of our experiments, we observed that macrocyclization was essential to obtain the desired multitarget profile. As a matter of example, the open precursors 35-37 were inactive against PIM whereas MCX 28 displayed low nanomolar activity. In the experiment, the researchers used many compounds, for example, 4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine).

4-Chloro-7-methylthieno[3,2-d]pyrimidine (cas: 175137-21-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Recommanded Product: 4-Chloro-7-methylthieno[3,2-d]pyrimidine

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia