On June 29, 2020, Mattelaer, Henri-Philippe; Van Hool, Anne-Sophie; de Jong, Flip; Van der Auweraer, Mark; Van Meervelt, Luc; Dehaen, Wim; Herdewijn, Piet published an article.SDS of cas: 4433-40-3 The title of the article was New Metal-Free Route towards Imidazole-Substituted Uridine. And the article contained the following:
Nucleosides with a bi(hetero)aryl nucleobase have unique potential applications as antiviral drugs and mol. probes. The need for transition metal catalysis to synthesize these nucleosides from pre-functionalized building blocks and the use of nucleobase protection groups results in expensive and tedious syntheses. Herein we report that 5-imidazolyl-uracil can be obtained by scalable Van Leusen imidazole synthesis and regioselectively introduced on ribose to obtain the desired nucleoside I and II in a 5 step synthesis (total yield 55%). The 5-imidazolyl moiety leads to improved fluorescence properties. The only side-product formed was characterized by 2D-NMR and X-ray crystallog. and could be suppressed during synthesis in favor of the desired product. Testing these newly accessed privileged structures against the current COVID-19 pandemic is currently underway. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).SDS of cas: 4433-40-3
The Article related to van leusen imidazole synthesis nucleoside fluorescence crystal structure vorbruggen, antiviral nucleoside heteroaryl nucleobase imidazolyluracil, fleximers, fluorescent probes, green chemistry, nucleobases, nucleosides and other aspects.SDS of cas: 4433-40-3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia