Treatment of primary acute genital herpes in guinea pigs by intraperitoneal administration of fluoropyrimidines was written by Mayo, Donald R.; Hsiung, G. D.. And the article was included in Antimicrobial Agents and Chemotherapy on September 30,1984.Recommanded Product: 69256-17-3 The following contents are mentioned in the article:
[1-(2′-Deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodocytosine] (FIAC)(I) [69123-90-6], [1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodouracil] (FIAU)(II) [69123-98-4], and [1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyluracil] (FMAU)(III) [69256-17-3] were evaluated for their efficacies in the treatment of genital infections with herpes simplex virus type 2 in guinea pigs. I.p. administration of these drugs in daily doses of 100 mg/kg of body weight initiated 24 h after virus inoculation and repeated 2 successive days thereafter inhibited development of genital lesions and reduced shedding of virus without evoking untoward reactions. In a comparative study with this 3-day dosage schedule, the efficacy of daily doses of 50 mg of FMAU per kg was greater than that of the same doses of FIAC and FIAU, in that order; all these were more effective than daily doses of 50, 100, or 200 mg of acyclovir or of 500 mg of phosphonoformic acid per kg. These differences in efficacy were enhanced when treatment was delayed for 2 to 3 days after inoculation. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Recommanded Product: 69256-17-3).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Recommanded Product: 69256-17-3
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3