Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling was written by Mcdermott, Ultan;Sharma, Sreenath V.;Dowell, Lori;Greninger, Patricia;Montagut, Clara;Lamb, Jennifer;Archibald, Heidi;Raudales, Raul;Tam, Angela;Lee, Diana;Rothenberg, S. Michael;Supko, Jeffrey G.;Sordella, Raffaella;Ulkus, Lindsey E.;Lafrate, A. John;Maheswaran, Shyamala;Njauw, Ching Ni;Tsao, Hensin;Drew, Lisa;Hanke, Jeff H.;Ma, Xiao-Jun;Erlander, Mark G.;Gray, Nathanael S.;Haber, Daniel A.;Settleman, Jeffrey. And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2007.Name: 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea The following contents are mentioned in the article:
Kinase inhibitors constitute an important new class of cancer drugs, whose selective efficacy is largely determined by underlying tumor cell genetics. The authors established a high-throughput platform to profile 500 cell lines derived from diverse epithelial cancers for sensitivity to 14 kinase inhibitors. Most inhibitors were ineffective against unselected cell lines but exhibited dramatic cell killing of small non-overlapping subsets. Cells with exquisite sensitivity to EGFR, HER2, MET, or BRAF kinase inhibitors were marked by activating mutations or amplification of the drug target. Although most cell lines recapitulated known tumor-associated genotypes, the screen revealed low-frequency drug-sensitizing genotypes in tumor types not previously associated with drug susceptibility. Furthermore, comparing drugs thought to target the same kinase revealed striking differences, predictive of clin. efficacy. Genetically defined cancer subsets, irresp. of tissue type, predict response to kinase inhibitors, and provide an important preclin. model to guide early clin. applications of novel targeted inhibitors. This study involved multiple reactions and reactants, such as 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7Name: 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea).
1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea (cas: 219580-11-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Name: 1-(tert-Butyl)-3-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia