On January 31, 2021, McKnight, Ian; Hart, Christoph; Park, In-Hyun; Shim, Joon W. published an article.Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Genes causing congenital hydrocephalus: Their chromosomal characteristics of telomere proximity and DNA compositions. And the article contained the following:
A review. Congenital hydrocephalus (CH) is caused by genetic mutations, but whether factors impacting human genetic mutations are disease-specific remains elusive. Given two factors associated with high mutation rates, we reviewed how many disease-susceptible genes match with (i) proximity to telomeres or (ii) high adenine and thymine (A + T) content in human CH as compared to other disorders of the central nervous system (CNS). We extracted genomic information using a genome data viewer. Importantly, 98 of 108 genes causing CH satisfied (i) or (ii), resulting in >90% matching rate. However, such a high accordance no longer sustained as we checked two factors in Alzheimers disease (AD) and/or familial Parkinsons disease (fPD), resulting in 84% and 59% matching, resp. A disease-specific matching of telomere proximity or high A + T content predicts causative genes of CH much better than neurodegenerative diseases and other CNS conditions, likely due to sufficient number of known causative genes (n = 108) and precise determination and classification of the genotype and phenotype. Our anal. suggests a need for identifying genetic basis of both factors before human clin. studies, to prioritize putative genes found in preclin. models into the likely (meeting at least one) and more likely candidate (meeting both), which predisposes human genes to mutations. The experimental process involved the reaction of 5-Methylpyrimidine-2,4(1H,3H)-dione(cas: 65-71-4).Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione
The Article related to review congenital hydrocephalus alzheimers parkinsons disease dna telomere, alzheimer’s disease, a + t content, mutation, chromosome, homologous recombination, familial parkinson’s disease, congenital hydrocephalus, telomeres and other aspects.Application In Synthesis of 5-Methylpyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia