McLaren, C. et al. published their research in International Congress Series in 1985 | CAS: 69256-17-3

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Computed Properties of C10H13FN2O5

Preclinical investigations of FIAU, an anti-herpes agent was written by McLaren, C.; Chen, M. S.; Barbhaiya, R. H.; Buroker, R. A.; Oleson, F. B.. And the article was included in International Congress Series in 1985.Computed Properties of C10H13FN2O5 The following contents are mentioned in the article:

The pharmacol. of FIAU (I) [69123-98-4] as an anti-herpes agent is described in relation to that of FIAC (II) [69123-90-6] and FMAU (III) [69256-17-3]. The mechanism of action of I is dependent on selective inhibition of viral thymidine kinase  [9002-06-6]. The I monophosphate [99891-31-3] and III monophosphate [94344-82-8] had better affinities for cellular thymidylate kinase  [9014-43-1] than for herpes simplex virus thymidine/thymidylate kinases. However, II monophosphate [99876-43-4] had poor affinities for either the cellular or herpes simplex virus enzymes. In cells exposed to 14C-labeled II, I monophosphate was the major metabolite, indicating that II is converted to the more active agent, I. I appeared to have good activity, but it had cardiotoxic and myelosuppressive activities. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3Computed Properties of C10H13FN2O5).

1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.Computed Properties of C10H13FN2O5

69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3