《A Convenient Late-Stage Fluorination of Pyridylic C-H Bonds with N-Fluorobenzenesulfonimide》 was published in Angewandte Chemie, International Edition in 2016. These research results belong to Meanwell, Michael; Nodwell, Matthew B.; Martin, Rainer E.; Britton, Robert. Synthetic Route of C6H7BrN2 The article mentions the following:
Pyridine features prominently in pharmaceuticals and drug leads, and methods to selectively manipulate pyridine basicity or metabolic stability are highly sought after. A robust, metal-free direct fluorination of unactivated pyridylic C-H bonds was developed. This convenient reaction shows high functional-group tolerance and offers complimentary selectivity to existing C-H fluorination strategies. Importantly, this late-stage pyridylic C-H fluorination provides opportunities to rationally modulate the basicity, lipophilicity, and metabolic stability of alkylpyridine drugs. Thus, e.g., mixing 4-ethylpyridine with NFSI in MeCN afforded 4-(1-fluoroethyl)pyridine (87%). The results came from multiple reactions, including the reaction of 5-Bromo-4-ethylpyrimidine(cas: 951884-36-9Synthetic Route of C6H7BrN2)
5-Bromo-4-ethylpyrimidine(cas: 951884-36-9) is a member of pyrimidine. Pyrimidine derivatives are an important class of N-heterocycles. They are well-known for their wide spectrum of promising biological activities such as antitumors, bactericidals, and fungicidal.Synthetic Route of C6H7BrN2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia