An Eco-Sustainable Synthetic Approach for 4,5-Dihydro-1H-pyrazoles via DBU Catalysis in Micellar Medium was written by Mishra, Anu;Rai, Pratibha;Pandey, Yogesh K.;Singh, Jaya;Singh, Jagdamba. And the article was included in ChemistrySelect in 2017.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine This article mentions the following:
An efficient and straightforward synthetic strategy for pharmaceutically pertinent scaffold 4,5-dihydro-1H-pyrazoles I [R1 = C6H5, 2-BrC6H4, 3,4-(OCH3)2C6H3, etc.; R2 = C6H5, 3,4-(CH3)2C6H3] has been reported initiating from highly substituted chalcones R1CH=CHC(O)R2 and thiosemicarbazide as reactants in an aqueous micellar medium by the use of DBU (1,8-Diazabicyclo[5.4.0]undec-7-ene) as an organobase. The use of CTAB (Cetyl Tri-Me Ammonium Bromide) as a surfactant, which forms a colloidal dispersion with organic substrates with the enhancement of the reactivity of substrates, is the key feature of this technique. Organic synthesis in aqueous micellar medium, use of organocatalyst DBU, mild reaction conditions, sustainable synthesis, exptl. feasibility, broad substrate scope, short reaction time and high yields are some other attributes of this protocol. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Recommanded Product: 4,6-Diphenylpyrimidin-2-amine).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Recommanded Product: 4,6-Diphenylpyrimidin-2-amine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia