Name: 2-Chloro-N-ethylpyrimidin-4-amineOn May 14, 2020 ,《Identification of 2-(4-(Phenylsulfonyl)piperazine-1-yl)pyrimidine Analogues as Novel Inhibitors of Chikungunya Virus》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Moesslacher, Julia; Battisti, Verena; Delang, Leen; Neyts, Johan; Abdelnabi, Rana; Puerstinger, Gerhard; Urban, Ernst; Langer, Thierry. The article conveys some information:
Arylsulfonyl and aroyl piperazinylpyrimidines such as I were prepared as antiviral agents against the chikungunya virus, the causative agent of chikungunya fever, and for their toxicities to uninfected Vero cells. Optimization of an arylsulfonylpiperazinylpyrimidinamine lead compound yielded I with an EC50 value against chikungunya virus of 3.95μM and cytotoxicity in Vero cells of 260μM.2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8Name: 2-Chloro-N-ethylpyrimidin-4-amine) was used in this study.
2-Chloro-N-ethylpyrimidin-4-amine(cas: 86443-51-8) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Name: 2-Chloro-N-ethylpyrimidin-4-amine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia