Nucleosides 11: synthesis of new derivatives of pyrido[2,3-d]pyrimidines and their nucleosides was written by Mohamed, Mosselhi A. M.;Abdel-Hafez, Shams H.;Gobouri, Adil A.. And the article was included in Nucleosides, Nucleotides & Nucleic Acids in 2021.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one This article mentions the following:
Reaction of 6-amino-2-methylthio-3-methyluracil with Et ethoxymethyleneoxaloacetate or methyl(Z)-2-acetylamino-3-dimethylaminopropenoates afforded di-Et 2-(1,6-dihydro-1-methyl-2-(methylthio)-6-oxo-pyrimidin-4-yl-amino)methylene malonate or (2E)-Me 3-(1,6-dihydro-1-methyl-2-(methylthio)-6-oxo-pyrimidin-4-yl-amino)-2-acetamidoacrylate, resp. Cyclization of each of the latter products by sodium ethoxide afforded new pyrido[2,3-d]pyrimidines, which were ribosylated with 1-O-acetyl-2,3,5-O-benzoyl-β-D-ribofuranose by the silylation method yielded the protected nucleosides. The protected nucleosides were debenzoylated by sodium methoxide to afford novel pyrido[2,3-d]pyrimidine nucleosides, e.g. I (R = CO2Et, NHAc). The structural assignments for the new compounds were based on their elemental anal. and spectroscopic data. In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Name: 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia