The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 3993-78-0, Name is 2-Amino-4-chloropyrimidine, SMILES is C1=CN=C(N=C1Cl)N, in an article , author is Goryaeva, Marina, V, once mentioned of 3993-78-0, Quality Control of 2-Amino-4-chloropyrimidine.
New multicomponent approach to polyfluoroalkylated pyrido [1,2-a] pyrimidine derivatives and bis-cyclohexenones
A one-pot three-component reactions between polyfluoroalkylated 3-oxo esters and methyl ketones with 1,3-diaminopropane result in 8-hydroxy-9a-alkyl(phenyl)-8-(polyfluomalkyl)octahydro-6H-pyrido [1,2-a] pyrimidin-6-ones, whereas a similar reaction with 1,4-diaminobutane forms a salt with trifluoroacetoacetic ester. In a two-component reaction, diamines with a long aliphatic chain (1,4-diaminobutane, 1,6-diaminohexane and 1,8-diaminooctane) react with an aldol derived from trifluoroacetoacetic ester and acetone, to give bis-cyclohexenones having an aliphatic linker. Using 2-(aminomethyl)aniline in a three-component reaction with polyfluomalky1-3-oxo esters leads to new 7-hydroxy-5a-alkyl(phenyl)-7-(polyfluomalkyl)-5a,6,7,8-tetrahydro-5H-pyrido [2,1-b] quinazolin-9(11H)-ones. Regioisomeric and spatial structures of new heterocycles were studied, and the mechanism of their formation was proposed. Some synthesized heterocycles were found to have moderate antiviral activity against influenza A/Puerto Rico/8/34 (H1N1) and Coxsackie B3 viruses.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia