Application of 671-35-2, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 671-35-2, Name is 5-Fluoro-4-hydroxypyrimidine, SMILES is O=C1NC=NC=C1F, belongs to pyrimidines compound. In a article, author is Sivakrishna, Balija, introduce new discover of the category.
Design, synthesis and cytotoxic evaluation of truncated 3 ‘-deoxy-3 ‘, 3 ‘ difluororibofuranosyl pyrimidine nucleosides
Truncated 3′-deoxy- 3′, 3′ difluororibofuranosyl pyrimidine nucleoside derivatives were synthesized from D-ribose via beta-apioribo pyrimidine nucleoside intermediates 11a-c. The synthetic approach signifies that truncation at C3’ position of apioribose ring of 13a-c by oxidative cleavage of diols with Pb(OAc)(4) and followed by fluorination with DAST as key steps. Cytotoxic evaluation of synthesized truncated nucleoside derivatives 16a-c and 19a-c were tested against MCF7 and MDA-MB-231 breast cancer cell lines. However, only 19a was shown minimal growth suppression activity on MDA-MB-231 cancer cell lines.
Application of 671-35-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 671-35-2.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia