In an article, author is de Sousa, Eduardo C., once mentioned the application of 873-83-6, Safety of 6-Aminopyrimidine-2,4(1H,3H)-dione, Name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1, MDL number is MFCD00006071, category is pyrimidines. Now introduce a scientific discovery about this category.
Nucleobase coupling by Mitsunobu reaction towards nucleoside analogs
The coupling of a nucleobase is a key step in the synthesis of most nucleoside analogs, e.g. carbocyclic nucleosides, isonucleosides and acyclic nucleosides. The synthetic strategies for nucleosides based on N-glycosylation are not applied when the nucleobase is not linked to the anomeric center. Thus, other methods have been employed, mainly those based on the alkylation of nucleobases. The Mitsunobu reaction, in which a hydroxy group is replaced by a nucleophile, has also been extensively applied, generating a diversity of molecules, including pharmaceuticals and their precursors. In this review the usefulness of this reaction for the coupling of nucleobases to non-anomeric positions of sugars, carbasugars and other homocyclic and linear structures is highlighted and discussed, covering purines and pyrimidines as pronucleophiles. [GRAPHICS] .
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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia