On July 14, 1998, Murugesan, Natesan; Barrish, Joel C.; Stein, Philip D. published a patent.Electric Literature of 160377-42-4 The title of the patent was Preparation of substituted biphenyl sulfonamides as endothelin antagonists. And the patent contained the following:
The title compounds [I; X, Y = N, O; R1, R2 = H, alkyl, alkoxy, OH, etc.; R3, R4 = H, alkyl, alkenyl, alkynyl, alkoxy, etc.; R5 = alkyl, alkenyl, alkynyl, etc.; R11-R14 = H, alkyl, alkenyl, alkoxy, etc.; J, K, T, U = N, C; p = 0-2] are prepared I are useful as endothelin antagonists for the treatment of endothelin-related disorders, hypertension, ischemia, atherosclerosis and related diseases (no data). Thus, N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-4′-(2-pyrimidinyl)-(1,1′-biphenyl)-2-sulfonamide (preparation given) was treated with aqueous HCl to provide 87% the title compound (II). The experimental process involved the reaction of 5-(4-Bromophenyl)pyrimidine(cas: 160377-42-4).Electric Literature of 160377-42-4
The Article related to sulfonamide biphenyl preparation endothelin antagonist, disorder hypertension ischemia atherosclerosis treatment sulfonamide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 160377-42-4
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia