Mylari, Banavara L.; Miller, Max W.; Howes, Harold L. Jr.; Figdor, Sanford K.; Lynch, John E.; Koch, Richard C. published the artcile< Anticoccidial derivatives of 6-azauracil. 1. Enhancement of activity by benzylation of nitrogen-1. Observations on the design of nucleotide analogs in chemotherapy>, Related Products of 4956-05-2, the main research area is coccidiostat benzylazauracil derivative; azauracil derivative anticoccidial.
Of >100 6-azauracil derivatives prepared and tested against Eimeria tenella infections in Leghorn cockerels, the 1-benzyl derivatives were most active, with maximum activity shown by 1-benzyl derivatives with compact, electron-withdrawing substituents such as 3′- or 4′-fluorine, -chlorine, or -nitrile substituents. The most active compound was 1-(3-cyanobenzyl)-6-azauracil (I) [27414-41-1], with a potency ∼16 times that of 6-azauracil [461-89-2]. I was also effective against E. maxima, E. acervulina, E. brunetti, and E. necatrix. Metabolism experiments using C-14-labeled 1-benzyl-6-azauracil [5991-46-8] showed no cleavage of the side chain. Structure-activity relations are discussed.
Journal of Medicinal Chemistry published new progress about Coccidiosis. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Related Products of 4956-05-2.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia