Synthesis and Antimicrobial Activity of Azolyl Pyrimidinyl Acetamides was written by N., Hussain Basha;T., Rekha;Guda, Dinneswara Reddy;Padmaja, Adivireddy;Padmavathi, V.. And the article was included in Polycyclic Aromatic Compounds in 2022.HPLC of Formula: 40230-24-8 This article mentions the following:
A variety of azolyl pyrimidinyl acetamides I (X = O, S, NH; Ar = Ph, 2-furyl, 4-pyridyl, etc.) were prepared from azolyl glycinate and 4,6-diaryl/heteroarylpyrimidinyl-2-amines in the presence of DMAP under ultrasonication. Nitrophenyl, pyridinyl and indolyl substituted thiazolyl pyrimidinyl acetamides, I (X = S; Ar = 4-O2NC6H4), I (X = S; Ar = 4-pyridyl), I (X = S; Ar = 3-indolyl) and imidazolyl pyrimidinyl acetamides I (X = NH; Ar = 4-O2NC6H4), I (X = NH; Ar = 4-pyridyl), I (X = NH; Ar = 3-indolyl) showed excellent antibacterial activity against B. subtilis and MBC is 2xMIC. The compounds, I (X = S; Ar = 4-O2NC6H4), I (X = NH; Ar = 4-O2NC6H4) and I (X = NH; Ar = 4-pyridyl) and also showed excellent antifungal activity against A. niger and MFC is 2xMIC. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8HPLC of Formula: 40230-24-8).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.HPLC of Formula: 40230-24-8
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia