On October 1, 2014, Na, Na; Shi, Ruixia; Long, Zi; Lu, Xin; Jiang, Fubin; Ouyang, Jin published an article.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione The title of the article was Real-time analysis of self-assembled nucleobases by Venturi easy ambient sonic-spray ionization mass spectrometry. And the article contained the following:
The real-time anal. of self-assembled nucleobases was employed by Venturi easy ambient sonic-spray ionization mass spectrometry (V-EASI-MS). With the anal. of three nucleobases including 6-methyluracil (6MU), uracil (U) and thymine (T) as examples, different orders of clusters centered with different metal ions were recorded in both pos. and neg. modes. Compared with the results obtained by traditional electrospray ionization mass spectrometry (ESI-MS) under the same condition, more clusters with high orders, such as [6MU7+Na]+, [6MU15+2NH4]2+, [6MU10+Na]+, [T7+Na]+, and [T15+2NH4]2+ were detected by V-EASI-MS, which demonstrated the soft ionization ability of V-EASI for studying the noncovalent interaction in a self-assembly process. Furthermore, with the injection of K+ to the system by a syringe pumping, the real-time monitoring of the formation of nucleobases clusters was achieved by the direct extraction of samples from the system under the Venturi effect. Therefore, the effect of cations on the formation of clusters during self-assembly of nucleobases was demonstrated, which was in accordance with the reports. Free of high voltage, heating or radiation during the ionization, this technique is much softer and suitable for obtaining the real-time information of the self-assembly system, which also makes it quite convenient for extraction samples from the reaction system. This “easy and soft” ionization technique provided a potential pathway for monitoring and controlling the self-assembly processes. The experimental process involved the reaction of 6-Methylpyrimidine-2,4(1H,3H)-dione(cas: 626-48-2).Name: 6-Methylpyrimidine-2,4(1H,3H)-dione
The Article related to self assembled nucleobase venturi sonic spray ionization mass spectrometry, cations, on-line analysis, real-time monitoring, self-assembled nucleobases, venturi easy ambient sonic-spray ionization mass spectrometry and other aspects.Name: 6-Methylpyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia