Discovery of the c-Jun N-Terminal Kinase Inhibitor CC-90001 was written by Nagy, Mark A.;Hilgraf, Robert;Mortensen, Deborah S.;Elsner, Jan;Norris, Stephen;Tikhe, Jayashree;Yoon, Won;Paisner, David;Delgado, Mercedes;Erdman, Paul;Haelewyn, Jason;Khambatta, Godrej;Xu, Li;Romanow, William J.;Condroski, Kevin;Bahmanyar, Sogole;McCarrick, Meg;Benish, Brent;Blease, Kate;LeBrun, Laurie;Moghaddam, Mehran F.;Apuy, Julius;Canan, Stacie S.;Bennett, Brydon L.;Satoh, Yoshitaka. And the article was included in Journal of Medicinal Chemistry in 2021.SDS of cas: 59549-51-8 This article mentions the following:
This manuscript reported the synthesis and structure-activity relationship (SAR) studies for a novel series of JNK inhibitors demonstrating an increased JNK1 bias. SAR optimization on a series of 2,4-dialkylamino-pyrimidine-5-carboxamides, e.g. I resulted in the identification of compounds possessing low nanomolar JNK inhibitory potency, overall kinome selectivity, and the ability to inhibit cellular phosphorylation of the direct JNK substrate c-Jun. Optimization of physicochem. properties in this series resulted in compounds that demonstrated excellent systemic exposure following oral dosing, enabling in vivo efficacy studies and the selection of a candidate for clin. development, CC-90001, which is currently in clin. trials (Phase II) in patients with idiopathic pulmonary fibrosis (NCT03142191). In the experiment, the researchers used many compounds, for example, 5-Bromo-2-chloro-4-(methylthio)pyrimidine (cas: 59549-51-8SDS of cas: 59549-51-8).
5-Bromo-2-chloro-4-(methylthio)pyrimidine (cas: 59549-51-8) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.SDS of cas: 59549-51-8
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia