Formula: C5H6N2O3On September 8, 2022 ,《Fragment Ligands of the m6A-RNA Reader YTHDF2》 was published in ACS Medicinal Chemistry Letters. The article was written by Nai, Francesco; Nachawati, Raed; Zalesak, Frantisek; Wang, Xiang; Li, Yaozong; Caflisch, Amedeo. The article contains the following contents:
17 Small-mol. ligands that compete with N6-methyladenosine (m6A) for binding to the m6A-reader domain of YTHDF2 (YT521-B homol. domain family 2) was reported. Their binding mode at high resolution was determined by X-ray crystallog. and their affinity was quantified by a fluorescence-based binding assay. 6-Cyclopropyluracil and a pyrazolopyrimidine derivative had favorable ligand efficiencies of 0.47 and 0.38 kcal mol-1 per non-hydrogen atom, resp. They represent useful starting points for hit optimization. In addition to this study using 6-Methoxypyrimidine-2,4(1H,3H)-dione, there are many other studies that have used 6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6Formula: C5H6N2O3) was used in this study.
6-Methoxypyrimidine-2,4(1H,3H)-dione(cas: 29458-38-6) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Formula: C5H6N2O3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia