The coloration reaction mechanism of 6-aminouracil derivatives with Ehrlich reagent and its application to the colorimetric determination method. II was written by Nakashima, Kenichiro. And the article was included in Yakugaku Zasshi in 1977.Product Details of 54030-56-7 This article mentions the following:
6-Amino-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine (I) [1004-40-6] and its N- or S-substituted derivatives are hydrolyzed by p-toluenesulfonic acid or HCl to the corresponding barbiturates. These barbiturates condense with the Ehrlich reagent [100-10-7] in the presence of an acid catalyst to afford stable benzylidene compounds These reactions were found to be almost quant. The optimal exptl. conditions were also established for using the above reactions for the quant. colorimetric determination of I derivatives In the experiment, the researchers used many compounds, for example, 6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7Product Details of 54030-56-7).
6-Amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one (cas: 54030-56-7) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Product Details of 54030-56-7
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia