As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 4,6-Diaminopyrimidine-2-thiol
Potassium hydroxide (88.8 g, 1.58 mol) and 4,6-diamino-2-mercaptopyrimidine (45.0 g, 316 mmol) were sequentially added to 230 ml of water and heated at 85 C. for 2 h.Add 220 ml of methanol, 1-bromo-3,3,3-trifluoropropane (280 g, 1.58 mol) and KI(2.63 g, 15.8 mmol), continued stirring at 60 C for 24 h. The reaction solution was concentrated under reduced pressure.After cooling to room temperature, the filter cake was dried to obtain 71.6 g of a yellow solid with a yield of 95%.
With the rapid development of chemical substances, we look forward to future research findings about 1004-39-3.
Reference:
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Lu Kuanying; Ma Zhilong; Jin Xunqi; Zhou Chao; (21 pag.)CN107973832; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia