Electric Literature of 10457-14-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10457-14-4, name is 2,4-Bis((trimethylsilyl)oxy)pyrimidine, molecular formula is C10H20N2O2Si2, molecular weight is 256.449, as common compound, the synthetic route is as follows.
To a solution of Compound 39 (927 mg, 2.00 mmol) in dry CH2CI2 (5 mL) was added HBr (1.16 mL, 4.28 mmol, 33% in AcOH) under N2. And the resultant mixture was stirred under N2 for 17 h. The reaction mixture was washed with twice H2O and NaHCC>3, dried (MgSC^) and concentrated under reduced pressure to give the crude bromide (838 mg) as a pale yellow oil. In a separate flask, uracil (269 mg, 2.40 mmol) and (NH4)2S04 (16 mg) in hexamethyldisilazane (5.0 mL) was heated to reflux under N2 for 22 h. The reaction mixture was concentrated under reduced pressure and dried under high vacuum to give the crude bis-TMS-uracil as a colorless oil. The crude bromide in dry CHCI3 (10 mL) was added to crude bis-TMS-uracil via cannula under N2. The resultant mixture was heated to reflux under N2 for 18 h and then quenched with H2O and stirred at RT for 30 min. The phases were separated and the aqueous phase was extracted twice with CH2CI2. The combined organic extracts were dried (MgS04) and concentrated under reduced pressure. Recrystalhzation from EtOH gave Compound 40 (598 mg) as a colorless solid.
Statistics shows that 10457-14-4 is playing an increasingly important role. we look forward to future research findings about 2,4-Bis((trimethylsilyl)oxy)pyrimidine.
Reference:
Patent; NOVADEX PHARMACEUTICALS AB; ZHOU, Xiao Xiong; TORSSELL, Staffan; WALLNER, Olov; SUN, Piaoyang; WO2011/75052; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia