New downstream synthetic route of 10457-14-4

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10457-14-4, 2,4-Bis((trimethylsilyl)oxy)pyrimidine, and friends who are interested can also refer to it.

Application of 10457-14-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10457-14-4, name is 2,4-Bis((trimethylsilyl)oxy)pyrimidine. A new synthetic method of this compound is introduced below.

To a stirred solution of 16 (3.4326 g, 8.2913 mmol, 1 eq.) in CH2Cl2 (100 mL) at 0 C, was added2,4-O,O-bis(trimethylsilyl)uracil (6.3677 g, 24.8739 mmol, 3 eq.) and trimethylsilytrifluoromethanesulfone(3.0 mL, 16.5826 mmol, 2 eq.) and stirring was continued at 0 C for 2h and atroom temp for 3 h. The reaction was quenched with saturated aq. NaHCO3 at 0 C. The organiclayer was separated and the aqueous layer was extracted with ethyl acetate. The organic layerswere combined and dried over MgSO4. Solvent was removed under reduced pressure and theresidue was purified by silica gel chromatography (hexanes-ethyl acetate, 1:1) to afford 17(3.1305 g, 94%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10457-14-4, 2,4-Bis((trimethylsilyl)oxy)pyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Kiran; Wakamatsu, Hideaki; Natori, Yoshihiro; Takahata, Hiroki; Yoshimura, Yuichi; Tetrahedron Letters; vol. 54; 30; (2013); p. 3949 – 3952;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia