1193-24-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1193-24-4, name is 4,6-Dihydroxypyrimidine, molecular formula is C4H4N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Add DCM (600ml) and POCl3 (80ml, 862mmol) to the reaction flask, stir evenly, and pass through nitrogenThe mixture was cooled to 5-10 C, and a solution of DMF (66.04 ml, 856 mmol) dissolved in DCM (200 ml) was added dropwise, and the mixture was stirred for 15-20 min, heated to 25-30 C, and stirred for 1-2 hours. 4,6-Dihydroxypyrimidine (80 g, 714 mmol) was added to the reaction mixture, and the reaction was carried out at 25-30 C for 22 hours, filtered, and the filter cake was washed twice with DCM (150 ml), dried, and vacuum at 40-45 C Drying gave 139.4 g of a yellow solid as the desired compound.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1193-24-4, 4,6-Dihydroxypyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; He Ji Whampoa Pharmaceutical (Shanghai) Co., Ltd.; Liu Bo; Zhang Bin; Yan Huixin; Ge Chongfeng; (16 pag.)CN108178748; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia