Reference of 13053-88-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13053-88-8, name is N-(Pyrimidin-2-yl)acetamide. A new synthetic method of this compound is introduced below.
A solution of 2-acpym (0.0184 g, 0.134 mmol) in CH2Cl2 (5 ml) containing three drops of NEt3 was added to a yellow suspension of 1 (0.0395 g, 0.067 mmol) in CH2Cl2 (10 ml). The yellow solution was stirred for 3 h, filtered and slow evaporation at room temperature gave a yellow precipitate which was recrystallized from CH2Cl2 and MeOH to give a yellow powder (0.041 g, 71%). Anal. Calc. for C17H15ClN4OPd, 47.1, H, 3.5, N, 12.9. Found: C, 47.3, H, 3.4, N, 13.2% IR (KBr) 3330s, 3170s, 3278s, 1649s, 1562s, 460 s cm-1. 1H NMR (dmso-d6) delta 9.42 (d, 1H, J 4.0), 8.66 (d, 1H, J 4.0), 8.57 (s, 1H, NH), 8.47 (s, 1H), 7.84 (dd, 1H, J 7.9, 4.0), 7.67 (d, 1H, J 7.9), 7.47 (d, 1H, J 7.9), 7.19 (dd, 1H, J 4.0, 4.0), 7.13 (dd, 1H, J 7.9, 4.0), 6.97 (dd, 1H, J 7.9, 3.8), 6.78 (dd, 1H, J 4.0, 4.0), 6.31 (d, 1H, J 7.9), 1.63 (s, 3H). Mp 182-184 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13053-88-8, its application will become more common.
Reference:
Article; Al-Jibori, Subhi A.; Gergees, Hayfa M.; Al-Rubaye, Mousa S.; Basak-Modi, Sucharita; Ghosh, Shishir; Schmidt, Harry; Laguna, Mariano; Luquin, M. Asuncion; Hogarth, Graeme; Inorganica Chimica Acta; vol. 450; (2016); p. 50 – 56;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia