Related Products of 14001-69-5, Adding some certain compound to certain chemical reactions, such as: 14001-69-5, name is 2-Methoxy-5-nitropyrimidine,molecular formula is C5H5N3O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14001-69-5.
Under 2 atmosphere, a suspension of 2-methoxy-5-nitropyrimidine (180 mg, 1.16 mmol, 1.00 equiv) and 5% Rh/C (13.8 mg, 0.60 moll Rh) in THF (11.6 mL, 0.100 M) was stirred at 23 C. Hydrazine monohydrate (69.7 mg, 1.39 mmol, 1.20 equiv) was added dropwise. The reaction 15 mixture was stirred at 23 C for 20 min. NaHCC>3 (117 mg, 1.39 mmol, 1.20 equiv) was added, followed by dropwise addition of a solution of acetyl chloride (109 mg, 1.39 mmol, 1.20 equiv) in THF (11.6 mL, 0.120 M) . The reaction mixture was stirred at 23 C for 30 min and then filtered through a short pad of celite. The celite was washed 20 with EtOAc. The combined organic solution was concentrated in vacuo. . The residue was purified by chromatography on silica gel, eluting with hexanes : EtOAc (2:1 to 0:1 (v/v)), to afford the title compound as a gray gum (125 mg, 0.682 mmol, 59% yield). Rf = 0.33 (EtOAc). NMR Spectroscopy: NMR (700 MHz, (CD3)2SO, 25 C, delta) : 10.93 (br. s, 1H) , 25 8.81 (s, 2H) , 3.91 (s, 3H) , 2.22 (br. s., 3H) . 13C NMR (175 MHz, (CD3)2SO, 25 C, delta) : 170.7, 161.8, 151.0, 131.8, 54.9, 21.6. Mass Spectrometry: HRMS (ESI-TOF) (m/z): calcd for C7H10N3O3 ( [M + H] + ), 184.0717, found, 184.0718.
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Reference:
Patent; THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK; NGAI, Ming-Yu; HOJCZYK, Katarzyna, N.; (214 pag.)WO2016/57931; (2016); A1;,
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