Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine. A new synthetic method of this compound is introduced below., Safety of 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine (0.5 g, 2.1 mmol) was dissolved in methanol (2 mL) and supplemented with te/t-butylamine (460.0 mg, 6.3 mmol). The reaction mixture was introduced in a sealed vessel and heated at 100C for 24 h. After concentration of the reaction mixture to dryness under vacuum, the residue was purified by silica gel column chromatography. Yield: 88%. Melting point: 88-89C. *H NMR (DMSO -d6) d 0.95 (t, J=7.3 Hz, 3H, SCH2CH2C/ ,), 1.43 (s, 9H, NHC(C/ ,)3), 1.62 (h, J=7.3 Hz, 2H, SCH2CH2CH3), 2.95 (t, J=7.3 Hz, 2H, SCH2CH2CH3), 4.91 (bs, 2H, NH2), 6.19 (s, 1H, NHC(CH3)3). 13C NMR (DMSO -d6) d 13.3 (SCH2CH2CH3), 22.9 (SCH2CH2CH3), 28.5 (NHC(CH3)3), 31.9(SCH2CH2CH3), 51.9 (NHC(CH3)3), 120.3 (C-5), 137.6 (C-6), 152.1 (C-4), 154.5 (C-2).
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Reference:
Patent; UNIVERSITE DE LIEGE; LANCELLOTTI, Patrizio; OURY, Cecile; PIROTTE, Bernard; (140 pag.)WO2019/158655; (2019); A1;,
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