The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 274693-26-4, name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C26H32F2N6O4S
Hydrochloric acid (3N, 24 mL) was added to a solution of 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylsulfanyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d](1,3)dioxol-4-yl)oxy)ethanol (6 g, Formula XI as obtained from Example 10) in methanol (30 mL). The reaction mixture was heated to 35C to 40C. The reaction mixture was stirred for 16 hours at 35C to 40C. Methanol was distilled off completely under vacuum at 30C to 35C to obtain a residue. The residue was extracted with dichloromethane (36 mL). The organic layer was washed with aqueous hydrochloric acid (IN, 30 mL) followed by washing with aqueous sodium bicarbonate solution (3 g in 30 mL) and deionized water (30 mL). The organic layer was distilled off to dryness to obtain a crude material. The crude material was purified with acetonitrile (30 mL) to afford the title compound. Yield: 4.16 g
With the rapid development of chemical substances, we look forward to future research findings about 274693-26-4.
Reference:
Patent; SUN PHARMACEUTICAL INDUSTRIES LIMITED; GOTTUMUKKALA, Nagaraju; SAINI, Anil; KHANNA, Mahavir, Singh; PRASAD, Mohan; (56 pag.)WO2016/38520; (2016); A1;,
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