New downstream synthetic route of 2-Amino-5-nitropyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3073-77-6, 2-Amino-5-nitropyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3073-77-6, name is 2-Amino-5-nitropyrimidine, molecular formula is C4H4N4O2, molecular weight is 140.1, as common compound, the synthetic route is as follows.Recommanded Product: 3073-77-6

A. Synthesis of N-(2-aminopyrimidin-5-yl)(tert-butoxy)carboxamide To a suspension of 2-amino-5-nitropyrimidine (0.25 g, 1.78 mmol) in methanol (4 mL) was added tert-butyl (tert-butoxycarbonyloxy)formate (0.5 mL, 2.18 mmol) and 10% Pd/C (96 mg, 0.090 mmol) under argon. The reaction mixture was hydrogenated under 1 atm H2 for 5 hr, filtered through Celite and concentrated in vacuo to give crude N-(2-aminopyrimidin-5-yl)(tert-butoxy)carboxamide (0.435 g). ES-MS (M+H)+=211.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3073-77-6, 2-Amino-5-nitropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Scarborough, Robert M.; Jantzen, Hans-Michael; Huang, Wolin; Sedlock, David M.; Marlowe, Charles K.; Kane-MaGuire, Kim A.; US2002/77486; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia