Electric Literature of 113583-35-0 ,Some common heterocyclic compound, 113583-35-0, molecular formula is C7H10N2O4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
At 40 to 45 C,2-[(Phenylamino)methyl]-1-azabenzene-3-ol (6.50 g, 32.46 mmol),4,6-dimethoxy-2-methylsulfonylpyrimidine (6.94 g, 31.81 mmol),Anhydrous potassium carbonate (11.22 g, 81.15 mmol)With anhydrous acetonitrile (100 mL)The mixture was stirred for 10 h,The reaction is over.The reaction mixture was filtered through a pad of celite.The filter cake was washed three times with a small amount of acetonitrile.The filtrate was concentrated to a pale yellow solid.The solid was isolated by flash chromatography eluting EtOAc EtOAcN-[2-(4,6-Dimethoxypyrimidinyloxy)-6-azabenzyl]phenylamine (1, 9.45 g, 86%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113583-35-0, its application will become more common.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Lv Long; Yang Zhengmin; Tang Qinghong; Fu Qunmei; (22 pag.)CN104844575; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
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