The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H4Cl2N2
[0059] Synthesis ofS5: ethyl 2-aminothiazole-5-carboxylate (1.0 g, 5.8 mmol) and 4,6- dichloro-2-methylpyrimidine (0.95 g, 5.8 mmol) were added to an oven dried flask. (0113) Dimethylformamide (20 mL) was then added. The reaction mixture was then cooled to 0 C, and sodium hydride (0.510 g, 12.8 mmol) was added. The reaction was allowed to warm to room temperature and stirred for an additional 3 hours. Excess base was quenched using ammonium chloride. The reaction was then suspended in water and filtered. After drying, the S5 was obtained as a white solid (1.4g, 81% yield). Spectral data: 1H NMR (400 MHz, DMSO-d6) delta 12.30 (s, 1H), 8.07 (s, 1H), 6.88 (s, 1H), 4.24 (q, J = 7.1 Hz, 2H), 2.54 (s, 3H), 1.26 (t, J = 7.1 Hz, 3H); 13C NMR (126 MHz, dmso) delta 167.85, 162.83, 161.96, 159.07, 157.88, 145.84, 122.02, 104.11, 61.22, 25.61,14.70; HRMS-ESI (m/z): [M + H]+ calcd for CnHnClN402S, 299.0364; found 299.0371.
With the rapid development of chemical substances, we look forward to future research findings about 1780-26-3.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; SOELLNER, Matthew, B.; PHADKE, Sameer; MERAJVER, Sofia, D.; (60 pag.)WO2017/87818; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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