In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2434-56-2, name is 4,6-Diaminopyrimidine, the common compound, a new synthetic route is introduced below. name: 4,6-Diaminopyrimidine
Compound 4,6-diaminopyrimidine 21a (70.0 mg, 0.6 mmol), 4-chloro-2-fluoropyridine (65.0 mg, 0.5 mmol) andN,N-Dimethylacetamide (5.0 mL) was added, and cesium carbonate (327.0 mg, 1 mmol) was added at room temperature, and stirred at 110 C for 3 hours.The mixture was quenched with 20 mL of water and the organic phase was separated. The aqueous phase was extracted with dichloromethane (15 mL¡Á2)Wash with saline (50 mL ¡Á 2). The organic phase is dried over anhydrous sodium sulfate, and the desiccant is removed by filtration, and the residue is evaporated to dryness.Purification by preparative silica gel plate (dichloromethane/methanol = 10:1) gave the desired product 4-(4-chloropyridin-2-yl)amino-6-aminoPyrimidine 21b (18.0 mg, 0.08 mmol, yellow solid). Yield: 16%.
The synthetic route of 2434-56-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Tianyinjianhua Pharmaceutical Technology Co., Ltd.; Kong Xianglong; Zhou Chao; Zheng Zhixiang; (105 pag.)CN109020957; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
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