Application of 1192064-63-3 , The common heterocyclic compound, 1192064-63-3, name is 2,5-Dichloro-4-methylpyrimidine, molecular formula is C5H4Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 2,5-dichloro-4-methylpyrimidine (300 mg, 1.6 mmol), (R)-tert-butyl 3- aminopyrrolidine-l-carboxylate (263 mg, 1.6 mmol) and DIEA (619 mg, 4.8 mmol) in DMF (5 mL) was stirred at l20C for 5 hours. The mixture was cooled to RT, diluted with water (20 mL) and extracted with EtOAc (20 mL* 3). The combined organic phase was washed with brine (20 mL), dried over Na2S04, filtered and concentrated. The residue was purified by flash chromatography on silica gel (petroleum ether/EtOAc = 20/1) to afford (R)-tert-butyl 3-((5-chloro- 4-methylpyrimidin-2-yl)amino)pyrrolidine-l-carboxylate (250 mg, 50%) as a yellow solid. [M+H] Calc?d for Ci4H2iClN402, 313.1; Found, 313.1.
The synthetic route of 1192064-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; KINNATE BIOPHARMA INC.; KANOUNI, Toufike; ARNOLD, Lee D.; KALDOR, Stephen W.; MURPHY, Eric A.; TYHONAS, John; (0 pag.)WO2020/6497; (2020); A1;,
Pyrimidine | C4H4N2 – PubChem,
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