Adding some certain compound to certain chemical reactions, such as: 271-80-7, name is 1H-Pyrazolo[3,4-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 271-80-7. 271-80-7
Compound 8a1 (1 g, 8.33 mmol) was dispersed in 1,2-dichloroethane, and N-iodosuccinimide (2.3 g, 9.02 mmol) and TDA-1 (0.5 ml). The mixture was refluxed at 90 C. After 3 h, the solvent was evaporated and the residue was extracted with hot water. The solid residue was dissolved in ethyl acetate and purified with flash chromatography. The product was obtained as yellowish solid. (1.9 g, 92.7 %). Rf (dichloromethane/MeOH 20:1) 0.34. 1H NMR (400 MHz, DMSO-d6): delta 9.04 (s, 1 H, C6-H), 9.08 (s, 1 H, C2-H), 14.51 (s, 1 H, NH). 13C NMR (101 MHz, DMSO-d6): delta 93.80, 118.55, 153.30, 154.73, 156.52.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 271-80-7.
Reference:
Article; Zhu, Junfei; Li, Zhiwen; Wang, Qi; Liu, Yang; He, Junlin; Bioorganic and Medicinal Chemistry Letters; vol. 26; 18; (2016); p. 4462 – 4465;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia