New downstream synthetic route of 289042-12-2

The synthetic route of 289042-12-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 289042-12-2, tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, blongs to pyrimidines compound. Safety of tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

10 g of tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4′-fluorophenyl)-6-isoIrIpyl-2- (methylamino)pyrimidin-5-yl)vinyl)-2,2-dimethyl- 1 ,3 -dioxan-4-yl)acetate of formula (4) and 100 mL of methylene dichloride was taken into 500 mL RBF. 25 g of triethylamine was added into the reaction mixture at 250C to 35AC. The reaction mixture was cooled to get -2O0C to -250C and treated with methane sulphonyl chloride. After maintaining for 1 hour under stirring, upon completion of reaction on TLC, the reaction mixture is quenched into 100 gm ice at 00C to 50C. Separated organic layer was washed with water and 80% methylene dichloride was distilled atmospherically at 4O0C to 500C. The reaction mixture was treated with 21 mL 10% sodium hydroxide solution and 100 mL methanol. The remaining methylene dichloride was removed azeI?lropically at 450C to 5O0C. After MDC removal, the reaction mixture was treated with 200 mL methanol and temperature was raised upto reflux for about 60AC to 650C for 6-8 hours. After the completion of the reaction on TLC, methanol was distilled under vacuum at 4O0C to 45AC.Further, the reaction mixture was treated with 20 mL of water and 50 mL of acetonitrile and cooled to O0C to 1O0C. The pH of the reaction mixture was adjusted using dil HCl at O0C to 1O0C. The organic layer was separated and treated with n-propyl amine to adjust the pH to about 8 to 9 at O0C to 1O0C. The reaction mixture was maintained at about 25AC to 350C for 1 hour. The product thus obtained was filtered and washed with chilled with acetonitrile. The solid was dried at 5O0C to 550C to obtain n-propyl amine salt of 2-((4R,6S)-6-((E)-2-(4-(4′-fluoroIhenyl)-6-isoIroIyl-2-(N- mI-thylmethylsulfonamido)pyriniidin-5-yl)vinyl)-2,2-dimethyl-l,3-dioxan-4-yl) acetic acid of formula (2′).

The synthetic route of 289042-12-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CADILA HEALTHCARE LIMITED; WO2009/157014; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia