Synthetic Route of 29274-22-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 29274-22-4, name is Pyrazolo[1,5-a]pyrimidin-5-ol. A new synthetic method of this compound is introduced below.
A mixture of the product (1.35 g, 10.0 mmol) from Step A above and 7.5 mL of phosphorus oxychloride was warmed at reflux for 4 h. The mixture was cooled, and the volatiles were removed under reduced pressure. The dark residue was partitioned between ice water and dichloromethane, and the aqueous layer was extracted with additional dichloromethane. The combined organic extracts were dried over sodium sulfate and concentrated under reduced pressure to provide a light brown solid, which was purified by flash chromatography (silica gel; 0.5% methanol in dichloromethane eluant) to afford the title compound as a white solid. MS 153.8 and 155.8 (M+1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,29274-22-4, Pyrazolo[1,5-a]pyrimidin-5-ol, and friends who are interested can also refer to it.
Reference:
Patent; MERCK & CO., INC.; WO2004/43940; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia