302964-08-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 302964-08-5, name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide. This compound has unique chemical properties. The synthetic route is as follows.
j00557j A solution of 1-(17-azido-3,6,9,12,15-pentaoxaheptadecyl)piperazine (1.50 g,4.00 mmol) in DMF (5 mL) was charged with potassium carbonate (1.10 g, 8.00 mmol) and 2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5 -carboxamide (1.58 g, 4.00 mmol). The resulting solution was heated at 100C for 16 h. Thereaction mixture was cooled to room temperature and filtered. The filtrate was concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 2% methanol in DCM to obtain 1.20 g, 36% yield of the title compound as an off white solid. ?H NMR (400 MHz, DMSO-d6): oe = 11.44 (s, 1H), 9.86 (s, 1H), 8.21 (s, 1H), 7.40(dd, J= 7.8, 1.9 Hz, 1H), 7.32 – 7.21 (m, 2H), 6.05 (s, 1H), 3.63 -3.54 (m, 27H), 3.42 -3.28 (m, 5H), 2.40 (s, 3H), 2.24 (s, 3H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 302964-08-5, 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide.
Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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