Synthetic Route of 32779-36-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 32779-36-5, name is 5-Bromo-2-chloropyrimidine. A new synthetic method of this compound is introduced below.
In portion wise, Cesium carbonate (6.78 g, 20.6 mmol) was added to a stirred solution of benzyl alcohol (2.25 g, 20.6 mmol) in acetonitrile and dimethylformamide (1:1, 40 mL) under nitrogen atmosphere at room temperature. After 10 min, 5-bromo-2-chloropyrimidine (2.0 g, 10.3 mmol) was added and the mixture was stirred at the same temperature for overnight. The reaction was monitored by TLC; after completion of the reaction, reaction mixture was poured into ice-cold water; the resultant solid was filtered; solid was washed with water (3 x 10 mL) followed by n-pentane (2 x 10 mL) and air dried and recrystallized from benzene gave 3a (2.675 g) as white solid in 97 percentyield, mp 102.9?105.6 ¡ãC, TLC Rf 0.34 (10 percent EtOAc in hexanes as the eluent); 1H NMR (DMSO, 300 MHz); delta 8.78 (s, 2H, Pyrimidine H), 7.34?7.47 (m, 5H, ArH), 5.38 (s, 2H, ArCH2); 13CNMR (DMSO, 100 MHz) delta 163.16,159.83, 136.15, 128.39, 128.02, 127.95, 111.91, 68.95; IR (KBr) 1271(C?O), 1179 (C?N), 525 (C?Br) cm-1; HRMS(ES+) exact mass calculated for [M+H]+ (C11H9BrN2O) requires m/z 264.989, found m/z 265.091, 267.301.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,32779-36-5, 5-Bromo-2-chloropyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Reddy, Onteddu Surendranatha; Suryanarayana, Ch. Venkata; Narayana; Anuradha; Babu, B. Hari; Medicinal Chemistry Research; vol. 24; 5; (2015); p. 1777 – 1788;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia