New downstream synthetic route of 335654-06-3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 335654-06-3, 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Application of 335654-06-3 ,Some common heterocyclic compound, 335654-06-3, molecular formula is C6H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

N-Bromosuccinimide (11374.5 g, 64.04 mol, 2.0 eq.) Was added portionwise to a solution of compound III (4907.0 g, 31.91 mol, 1.0 eq.) In acetonitrile Completed, at room temperature (25 ) for 17 hours, monitoring the reaction was complete.The reaction solution was slowly added to 100L of ice water, precipitated a large amount of solid, suction filtration, the filter cake washed with water (50L × 3), dried to obtain 7117.2g white white solid.Yield: 95.82%.1H-NMR (400 MHz, DMSO-d6) delta (ppm) 12.78 (brs, 1H); 8.85 (s, 1H); 7.89 (s, 1H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 335654-06-3, 2-Chloro-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing Furunkaide Bio-pharmaceutical Co., Ltd.; Rong Liang; Li Jin; Li Hui; Jie Yuanping; Wu Xihan; Yang Minmin; (12 pag.)CN105949196; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia