New downstream synthetic route of 36082-50-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Related Products of 36082-50-5 ,Some common heterocyclic compound, 36082-50-5, molecular formula is C4HBrCl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

ntermedate Iyi2coro56dilidrogm .d [4J,jjflpje7carbox(jata(amo-2-chloro-rimidin-4-amineTo a solution of 5-bromo-2,4dichloro-pyrimidine (150 g; 658 mmol) in THE (445 mL) was added ammoniumhydroxide (25% in water, 250 mL) and the resufting reaction mixture was stirred at room temperature for 90 mm. The mixture was subsequently evaporated to a small volume and partitioned between ethyl acetate and water. The organic phase wasseparated and washed with water and brine, dried over sodium sulfate, filtered andconcentrated to give 137.3 g (quant. yield) of 5-bromo2-chloro-pyrimidin4-amine.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.; DE MAN, Adrianus Petrus Antonius; BUIJSMAN, Rogier Christian; STERRENBURG, Jan Gerard; UITDEHAAG, Joost Cornelis Marinus; DE WIT, Joeri Johannes Petrus; ZAMAN, Guido Jenny Rudolf; WO2015/155042; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia