Adding a certain compound to certain chemical reactions, such as: 36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-4,6-dimethoxypyrimidine, blongs to pyrimidines compound. Safety of 2-Amino-4,6-dimethoxypyrimidine
One pot procedure for the synthesis of 2-amino-5,7-dimethoxy [1,2, 4] triazolopyrimidine (ADTP) from 2-amino-4,6-dimethoxypyrimidine (ADP) 11. 9 g (0.075 mol) ADP was dissolved in 68 g ethyl acetate. 11 g (0.0825 mol) ethoxycarbonyl isothiocyanate was added within 20 min. at 78C (no exotherm). The mixture was stirred over 5 h at reflux (78-79C). 49.2 g (0.075 mol) hydroxylammonium sulfate (25 % solution in water) were added and the mixture heated to 71C (reflux aceotrope). 50 g (0.1 mol) diluted caustic soda (2 mot/1) was added within 1 h to establish the pH from 1.3 to 6.5 and hold at 6.5-7. 0 (offgas C02 and H2S, slightly exotherm). The mixture was stirred over 6 h under reflux (71C) for reaction completion. The mixture was cooled down over night to 20C. The product (ADTP) was filtrated and washed 3 times with each 25 g water to remove the salt (Na content after first wash 0.42 %, after second 0.20 %, after third 0.025 %). Finally the solid ADTP was dried. Yield : 91.1 % in respect to ADP, purity 95.3 % (quantitative HPLC assay).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; BASF AKTIENGESELLSCHAFT; WO2005/63753; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia